Clinical Trials

IRB Protocol Number Study Title PI Name Protocol Status Study Nature
206069 Molecular epidemiology and transmission of Clostridium difficile infections in nosocomial settings Kothari,Atul Open biomedical-clinical
217603 Biomarkers of Rheumatoid Arthritis (RA) Khan,Nasim Draft biomedical-clinical
203199 “Vaccination of Advanced-Stage Lung Cancer Patients” A Phase I/II Study of a Carbohydrate Mimotope Based Vaccine with MONTANIDETM ISA 51 VG ST Adjuvant Arnaoutakis,Konstantinos Open biomedical-clinical
113597 Reactive hemophagocytic Syndrome in the Intensive Care Unit Meena,Nikhil Open biomedical-clinical
203096 Attitudes Regarding Smoking Cessation among Resident Physicians – A Single Center Cross- Sectional Survey. Kenchaiah,Satish Draft social-behavioral-education
204850 GO29831: A Phase IB, Open-Label Study Evaluating the Safety and Pharmacokinetics of Atezolizumab (Anti-Pd-L1 Antibody) in Combination with Trastuzumab Emtansine or with Trastuzumab and Pertuzumab (with and without Docetaxel) in Patients with HER2 Positive Breast Cancer and Atezolizumab with Doxorubicin and Cyclophosphamide in HER2-Negative Breast Cancer Makhoul,Issam Open biomedical-clinical
6364 SWOG N9831 Phase III Trial of Doxorubicin and Cyclophosphamide (AC) followed by Weekly Paclitaxel with or without Trastuzumab as Adjuvant Treatment for Women with HER 2 Overexpressing or Amplified Node Positive or High Risk Node Negative Breast Cancer Hutchins,Laura Open biomedical-clinical
202759 Evaluation of Cancer Stem Cells Before and After Neoadjuvant Treatment for Breast Cancer and Their Correlation With Local and Distant Recurrence Makhoul,Issam Open biomedical-clinical
106804 North American Juvenile Myelomonocytic Leukemia Project Emanuel,Peter Open biomedical-clinical
205575 Femara (Letrozole) Plus Ribocictib (LEE011) or Placebo as Neo-adjuvant Endocrine Therapy for Women with ER-positive, HER2-negative Early Breast Cancer Makhoul,Issam Open biomedical-clinical
29014 SWOG 0221 Phase III Trial of Continuous Schedule AC G Vs Q 2 week Schedule AC Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post Operative Adjuvant Therapy in Node Positive or High Risk Node Negative Breast Cancer Hutchins,Laura Open biomedical-clinical
205168 Phase 2 Single Arm Trial of Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients with Incurable Head and Neck Squamous Cell Carcinoma (HNSCC) – Protocol #201410073 Atiq,Omar Open biomedical-clinical
205167 Correlation between arterial stiffness and diastolic function reserve index during dobutamine stress in diabetes mellitus Vallurupalli,Srikanth Open biomedical-clinical
205062 Maintaining Attention Span and Concentration in the Classroom Makhoul,Issam Open social-behavioral-education
205543 Rapid treatment with Pleural Indwelling catheter (RAPID) with talc instillation for recurrent pleural Effusion Meena,Nikhil Open biomedical-clinical
57485 (IRB# 57485) UARK 2004 19 Randomized Double Blind Multicenter Phase II Study of Time to Progression on Fulvestrant in Combination with Erlotinib or Placebo in Hormone Receptor Positive Metastic Breast Cancer (MBC) Subjects who Progressed on First Line Hormonal Therapy Makhoul,Issam Open biomedical-clinical
110396 (IRB#110396) Vaccination of High Risk Breast Cancer Patients Hutchins,Laura Open biomedical-clinical
203989 A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy with Nivolumab versus Ipilimumab after Complete Resection of Stage IIIb/c or Stage IV Melanoma in Subjects who are at High Risk for Recurrence Hutchins,Laura Open biomedical-clinical
205349 Retrospective analysis of outcomes and complications of concomitant versus sequential performance of diagnostic thoracentesis and biopsy Meena,Nikhil Open biomedical-clinical
205751 Complications of ports used for chemotherapy administration – a chart review Makhoul,Issam Open biomedical-clinical
205215 Identification of novel urine biomarkers for early detection and risk prediction in cisplatin induced Acute Kidney Injury (AKI). Karakala,Nithin Open biomedical-clinical
204887 Are steroids effective for para-influenza infection in immunocompromised patients? Meena,Nikhil Open biomedical-clinical
205952 A Phase 2, Double-Blind, Randomized Study Evaluating the Safety, Tolerability, and Efficacy of GS-4997 in Combination with Prednisolone versus Prednisolone Alone in Subjects with Severe Alcoholic Hepatitis (AH) Garciasaenzdesicilia,Mauricio Open biomedical-clinical
205747 Ultrasound-guided Inferior Vena Cava (IVC) Measurement in the Management of Patients with Septic Shock Karakala,Nithin Open biomedical-clinical
202863 E1912 A Randomized Phase III Study of Ibrutinib (PCI-32765) based Therapy vs Standard Fludarabine, Cyclophosphamide, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL) Motwani,Pooja Open biomedical-clinical
41006 (IRB #41006) UARK 2004 59 Primary Systemic Therapy using Sequential Docetaxel Cyclophosphamide Bevacizumab followed by Doxorubicin in Operable Locally Advanced Breast Cancer Makhoul,Issam Open biomedical-clinical
202151 A Randomized, Open-Label, Multicenter, Controlled Study to Assess Safety and Efficacy of ELAD in Subjects with Alcohol-Induced Liver Decompensation (AILD) Duarterojo,Andres Open biomedical-clinical
205108 Epidemiology of Respiratory Syncytial Virus infections in Multiple Myeloma KOTHARI,ATUL Open biomedical-clinical
112748 A Phase II Study to Assess the Efficacy and Safety of Preoperative Chemotherapy with Radiation therapy for Patients with Unresectable Adenocarcinoma of the Pancreas Makhoul,Issam Open biomedical-clinical
203291 Sickle Cell Anemia Patient Registry MOTWANI,POOJA Open biomedical-clinical
204755 A phase Ib/II, open-label, multicenter trial with oral cMET inhibitor INC280 alone and in combination with erlotinib versus platinum/pemetrexed in adult patients with EGFR mutated, cMET-amplified, locally advanced/metastatic non-small cell lung cancer (NSCLC) with acquired resistance to prior EGFR tyrosine kinase inhibitor (EGFR TKI) Arnaoutakis,Konstantinos Open biomedical-clinical
204121 Epidemiology of bacteremias following autologous stem cell transplantation for multiple myeloma Kothari,Atul Open biomedical-clinical
73947 UARK 2006 44 A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Treatment with 2 mg Intralesional Allovectin 7 Compared to Dacarbazine (DTIC) or Temozolomide (TMZ) in Subjects with Recurrent Metastatic Melanoma Hutchins,Laura Closed biomedical-clinical
204122 Evaluating the impact of formal symptom management curriculum to Hematology/Oncology Fellows Mahmoud,Fade Open social-behavioral-education
204261 Surrogate markers for Histoplasmosis capsulatum disease Novack,Amanda Draft biomedical-clinical
6809 SWOG 0016 A Phase III Trial of CHOP vs CHOP Rituximab vs CHOP Iodine 131 Labeled Monoclonal Anti B1 Antibody (Tositumomab) for Treatment of Newly Diagnosed Follicular Non Hodgkin s Lymphomas Hutchins,Laura Open biomedical-clinical
201801 Influenza Survey Joshi,Manish Open biomedical-clinical
206708 Effects of Resistant Starch Diet on the Gut Microbiome in Chronic Kidney Disease Arthur,John Open biomedical-clinical
204143 Expansion of Utilization of Telemedicine to Improve Rates of Home Dialysis UAMS IRB #202323 Easom,Andrea Draft social-behavioral-education
204500 A Randomized, Open-Label Phase 2 Study of Denintuzumab Mafodotin (SGN-CD19A) Plus Rituximab, Ifosfamide, Carboplatin, and Etoposide (19A +RICE) Chemotherapy vs. RICE in the Treatment of Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) who are Candidates for Autologous Stem Cell Transplant MOTWANI,POOJA Open biomedical-clinical
204786 Racial disparities in readmission, complications and surgical procedures in adults with inflammatory bowel diseases Duarterojo,Andres Open biomedical-clinical
203261 Lymphopenia as a Prognostic Marker for Non-Small Cell (NSCLC) and Small Cell Lung Cancer (SCLC): A Retrospective Chart Review Arnaoutakis,Konstantinos Open biomedical-clinical
203056 S1222 Fulvestrant Alone Versus Fulvestrant and Everolimus versus Fulvestrant, Everolimus and Anastrozole: A Phase III Randomized Placebo- Controlled Trial in Postmenopausal Patients with Hormone-Receptor Positive Stage IV Breast Cancer Hutchins,Laura Open biomedical-clinical
205283 A Randomized, Double-Blind Phase 3 Study of Vadastuximab Talirine (SGN-CD33A) Versus Placebo in Combination with Azacitidine or Decitabine in the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) SGN33A-005 Veeraputhiran,Muthu Open biomedical-clinical
204603 Alliance A091105, A Phase III, Double Blind, Randomized, Placebo-Controlled Trial of Sorafenib in Desmoid Tumors or Aggressive Fibromatosis (DT/DF) Govindarajan,Rangaswamy Open biomedical-clinical
202493 G551D Observational Study – Expanded to Additional Genotypes and Extended for Long Term Follow-up (GOAL-e²) Johnson,Larry Open biomedical-clinical
205485 Fourth International Study of Mechanical Ventilation Meena,Nikhil Open biomedical-clinical
205290 Stent inflation time in coronary artery chronic total occlusions Vallurupalli,Srikanth Open biomedical-clinical
28757 (IRB# 28757) CTSU E1697 Phase III Randomized Study of Four Weeks High Dose IFN a2b in Stage T2b No T3a bNo and T1 4 N1a 2a (microscopic) Melanoma Hutchins,Laura Open biomedical-clinical
204532 EA6134, A Randomized Phase III Trial of Dabrafenib + Trametinib Followed by Ipilimumab + Nivolumab at Progression vs. Ipilimumab + Nivolumab Followed by Dabrafenib + Trametinib at Progression in Patients with Advanced BRAFV600 Mutant Melanoma Mahmoud,Fade Open biomedical-clinical
132340 SWOG 0931, EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy, A Phase III Study Hutchins,Laura Open biomedical-clinical
202377 A pilot, feasibility study to evaluate the presence of EZH2 expression and miRNA-101 in the peripheral blood of patients with castration resistant prostate cancer ARNAOUTAKIS,KONSTANTINOS Open biomedical-clinical
66222 (IRB# 66222) CTSU E2805 ASSURE Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Carcinoma Govindarajan,Rangaswamy Open biomedical-clinical
204543 EZH2 in Melanomagenesis Mahmoud,Fade Open biomedical-clinical
206816 Validation of Cognitive Tests in Elderly Cirrhotic Patients Duarterojo,Andres Open biomedical-clinical
138895 Left Ventricular function post myocardial infarction in diabetic patient using metformin as compared to non diabetic patients or diabetic patients not using metformin, a retrospective study Abualsuod,Amjad Open biomedical-clinical
203224 S1400 Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer ARNAOUTAKIS,KONSTANTINOS Open biomedical-clinical
203017 A Phase 3b Randomized Study of Lenalidomide (CC-5013) plus Rituximab Maintenance Therapy Followed by Lenalidomide Single-Agent Maintenance Versus Rituximab Maintenance in Subjects with Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma Motwani,Pooja Open biomedical-clinical
203720 A Registry Study to Evaluate the Survival and Long-Term Safety of Subjects Who Previously Received Talimogene Laherparepvec in Amgen or BioVEX-Sponsored Clinical Trials Mahmoud,Fade Open biomedical-clinical
206351 Confirmation of nasogastric tube placement by pH testing Meena,Nikhil Expedited IRB Review biomedical-clinical
204344 A Phase III, Open-Label, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (ANTI-PD-L1 ANTIBODY) Compared with Best Supportive Care Following Adjuvant Cisplain-Based Chemotherapy in PD-L1-Selected Patients with Completely Resected Stage IB-IIIA Non-Small Cell Lung Cancer ARNAOUTAKIS,KONSTANTINOS Open biomedical-clinical
206265 Vaccination of Patients with Metastatic Cancer Makhoul,Issam Open biomedical-clinical
3850 RTOG 94-08 A Phase III Trial of the Study of Endocrine Therapy Used as a Cytoreductive and Cytostatic Agent Prior to Radiation Therapy in Good Prognosis Locally Confined Adenocarcinoma of the Prostate Penagaricano,Jose Open biomedical-clinical
204334 Changing trends in antimicrobial susceptibility of Enterococci and role of antibiotic usage in patients with cancer Kothari,Atul Open biomedical-clinical
207179 Outcomes of Parainfluenza Respiratory Viral Infections in Multiple Myeloma Patients Burgess,Mary Open biomedical-clinical
133529 (IRB#133529) CTSU E1609, A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Versus High-Dose Interferon a – 2b for Resected High-Risk Melanoma Govindarajan,Rangaswamy Open biomedical-clinical
202457 Assessment of Quality of Life Outcomes Among Breast Cancer Patients and their Partners After Primary Treatment Makhoul,Issam Open biomedical-clinical
204322 S1207 “Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer” e3 Breast Cancer Study- evaluating everolimus with endocrine therapy Makhoul,Issam Open biomedical-clinical
207524 Parallel-Group, Placebo-Controlled Randomized Study Investigating the Effect of Intravenous Iso-osmolar Iodinated Contrast Material Iodixanol (Visipaqueâ„¢ Injection 320 mgI/mL) on Renal Function in Adults with Chronic Kidney Disease (CKD) Stage III or Stage IV Who Have Undergone Endovascular Aneurysm Repair (EVAR) Singh,Manisha Draft biomedical-clinical
135910 A Multicenter, Double-blind, Placebo-controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-resection Melanoma Patients with a High Risk of Recurrence Mahmoud,Fade Open biomedical-clinical
206533 Utility of inferior lead Q waves as a predictor of Ventricular Tachycardia in Wide Complex Tachycardia Subramany,Swathi Open biomedical-clinical
204456 Biological Study of Juvenile Myelomonocytic Leukemia (JMML) Liu,Yunying Open biomedical-clinical
206797 A Phase 1/2 Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis Johnson,Larry Open biomedical-clinical
206795 Identification of clinical markers in Acute Kidney Injury using the United States Renal Data System for follow-up information. Arthur,John Open biomedical-clinical
202323 Utilization of Telemedicine to Improve Rates of Home Dialysis Easom,Andrea Open social-behavioral-education
113814 SWOG 0337 A Phase III Blinded Study of Immediate Post-TURBT Instillation of Gemcitabine Versus Saline in Patients with Newly Diagnosed or Occasionally Recurring Grade I/II Superficial Bladder Cancer Kamel,Mohamed Open biomedical-clinical
206790 A Phase III, randomized, double-blind, placebo-controlled study of AeroVanc for the treatment of persistent methicillin-resistant Staphylococcus aureus lung infection in cystic fibrosis patients Jagana,Rajani Open biomedical-clinical
204672 NRG-BR003, A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer Makhoul,Issam Open biomedical-clinical
204474 An Open-label, Randomized, Phase 3 Study of Nivolumab or Chemotherapy in Subjects with Relapsed Small-cell Lung Cancer after Platinum-based First Line Chemotherapy (CheckMate 331: CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 331) Arnaoutakis,Konstantinos Open biomedical-clinical
204374 A Pilot Study To Assess The Immunogenicity Of Candidate PSA Peptides For A Prostate Cancer Vaccine ARNAOUTAKIS,KONSTANTINOS Open biomedical-clinical
204560 Usefulness of Controlled Attenuation Parameter (CAP) for the assessment of liver steatosis in liver donors Duarterojo,Andres Open biomedical-clinical
203603 NRG-GI001, Randomized Phase III Study Of Focal RadiationTherapy For Unresectable, Localized Intrahepatic Cholangiocarcinoma SCHAFER,LIUDMILA Open biomedical-clinical
202556 “Vaccination of High Risk Breast Cancer Patients” A Combined Phase I/II Feasibility-and-Efficacy Study of a Carbohydrate Mimotope-based Vaccine with MONTANIDEâ„¢ ISA 51 VG STERILE Combined with Neoadjuvant Chemotherapy Hutchins,Laura Open biomedical-clinical
202416 A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE) in Patients with Metastatic, GPNMB Over-Expressing, Triple-Negative Breast Cancer (The “METRIC” Study) Makhoul,Issam Open biomedical-clinical
206773 A 5-year Longitudinal Observational Study of the Natural History and Management of Patients with Hepatocellular Carcinoma Garciasaenzdesicilia,Mauricio Open biomedical-clinical
204693 A Phase II, Multicenter, Four-Cohort Study of Oral cMET Inhibitor INC280 in Adult Patients with EGFR Wild-Type (wt), Advanced Non-Small Cell Lung Cancer (NSCLC) who have Received One or Two Prior Lines of Systemic Therapy for Advanced/Metastatic Disease Arnaoutakis,Konstantinos Open biomedical-clinical
204697 Safety of anti-arrhythmic drug use in tachycardia mediated cardiomyopathy Vallurupalli,Srikanth Open biomedical-clinical
68239 (IRB# 68239) CTSU PACCT 1 Program for the Assessment of Clinical Cancer Tests (PACCT 1) Trial Assigning IndividuaLized Options for Treatment The TAILORx Trial Govindarajan,Rangaswamy Open biomedical-clinical
204351 CTSU EAY131 Molecular Analysis for Therapy Choice (MATCH) Govindarajan,Rangaswamy Open biomedical-clinical
6417 SWOG 0008 Phase III Trial of High Dose Interferon Alpha 2b Versus Cisplatin Vinblastine DTIC Plus IL 2 and Interferon in Patients with High Risk Melanoma Hutchins,Laura Open biomedical-clinical
203618 Protocol number: M11-001 An observational, Non-Interventional, Multi-Center, Multi-National Study of Patients with Atypical Hemolytic-Uremic Syndrome (AHUS Registry) MOTWANI,POOJA Open biomedical-clinical
203513 CTSU E1910 A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-negative B Lineage Acute Lymphoblastic Leukemia in Adults MOTWANI,POOJA Open biomedical-clinical
77034 UARK 2006-53 Cetuximab Related First Infusion Reaction Rate in Cancer Patients Makhoul,Issam Open biomedical-clinical
205605 Biomarkers of Kidney Diseases Arthur,John Open biomedical-clinical
205607 SWOG 1404, A Phase III Randomized Trial Comparing Physician/Patient Choice of Either High Dose Interferon or Ipilimumab to MK-3475 (Pembrolizumab) in Patients with High Risk Resected Melanoma Mahmoud,Fade Open biomedical-clinical
205655 Microbiome-derived Therapeutic Targets for Chronic Kidney Disease Arthur,John Open biomedical-clinical
205611 Prospective Study on Respiratory Viral Infections as Cause of Morbidity in Cancer Patients KOTHARI,ATUL Open biomedical-clinical
111245 (IRB# 111245) The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia Emanuel,Peter Open biomedical-clinical
207475 A Pilot Study to Assess Feasibility of Studying Gut Microbiome of Patients with Head and Neck Cancer Atiq,Omar Open biomedical-clinical
205782 USRDS Claims Study to Explore Comparative Evaluation of Effectiveness and Safety of Clopidogrel, Prasugrel and Ticagrelor among ESRD Patients Jain,Nishank Open biomedical-clinical
206009 Multicenter survey of secondary prophylaxis in invasive fusariosis in patients with hematologic diseases Rico,Juan Open biomedical-clinical
207447 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis Johnson,Larry Draft biomedical-clinical
5991 SWOG 9921 Adjuvant Androgen Deprivation versus Mitoxantrone Plus Prednisone Plus Androgen Deprivation in Selected High Risk Prostate Cancer Patients Following Radical Prostatectomy Phase III Hutchins,Laura Open biomedical-clinical
206010 A Combined Phase I/II Efficacy Study of a Carbohydrate Mimotope-based Vaccine with MONTANIDEâ„¢ ISA 51 VG Combined with Neoadjuvant Chemotherapy in Triple Negative Breast cancer Makhoul,Issam Open biomedical-clinical
203655 S1320, “A Randomized, Phase II Trial of Intermittent Versus Continuous Dosing of Dabrafenib (NSC-763760) and Trametinib (NSC-763093) in BRAFV600E/K Mutant Melanoma.” Hutchins,Laura Open biomedical-clinical
203659 A physical activity program in end-stage liver disease: pilot study assessing changes in physical fitness, sarcopenia, and the metabolic profile Duarterojo,Andres Open biomedical-clinical
137871 137871 An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (ADAPT) ARNAOUTAKIS,KONSTANTINOS Open biomedical-clinical
206429 Functional Assessment in Liver Transplantation (FrAILT) Study Duarterojo,Andres Open biomedical-clinical
26779 SWOG E4697 A Randomized Placebo Controlled Phase III Trial of Yeast Derived CM CSF Versus Peptide Vaccination Versus GM CSF Plus Peptide Vaccination Versus Placebo in Patients with No Evidence of Disease after Complete Surgical Resection of Locally Advance and or Stage IV Melanoma Hutchins,Laura Open biomedical-clinical
203536 Guiding Introducer RAMPâ„¢ sheath use in Atrial flutter ablation. Achanta,Latha Open biomedical-clinical
206048 A 5-year Longitudinal Observational Study of Patients with Primary Biliary Cholangitis Dranoff,Jonathan Open biomedical-clinical